Investigation of aromatase inhibitors’ ability to affect pathways required for endometriosis formation

    Author Name(s)

    Alexis Figueroa

    Faculty Advisor(s)



    Senolytic drugs are being studied for their ability to selectively clear out (or kill) senescent cells that lead to aging, tissue damage, and potentially fatal diseases. This project aims to determine if senolytic agents could potentially be used for the treatment of endometriosis. Endometriosis is a gynecological disease in which endometrial (uterine lining) tissue implants itself outside of the uterus. Endometriosis affects 10-15% of women and currently has no known cause or cure. Through the use of Molsoft Software to evaluate protein docking, the binding strength can be predicted between enzymes and senolytic drugs. This study examines whether Aromatase inhibitors can interact with BCL-2. It was found that these drugs are not predicted to affect the pathway required for endometriosis formation.


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