Author Name(s) Carmen Cortez Ortega Faculty Advisor(s) Blake Gillespie Abstract Understanding yeast’s contribution to flavor development in beer brewing often requires rapid, reproducible extraction of volatiles from aqueous solution for mass spectral analysis. HS-SPME is a time consuming process in which reproducibility is a challenge. A more efficient process is dispersive liquid-liquid microextraction (DLLME). In comparison to HS-SPME, DLLME allows many samples to be rapidly and simultaneously extracted. Using volatiles… Read More »A comparison of beer volatiles extraction using HS-SPME and DLLME for analysis by GC-MS
Modeling the Stability of the High-Density Lipoprotein Particle by Examining the Protein-to-Protein Binding Strengths.
Author Name(s) Cynthia Fernandez Faculty Advisor(s) William Munroe Abstract Our research focuses on modeling the stability of the human High-Density Lipoprotein (HDL) particle and understanding its characteristics. As we did protein-protein docking, we were able to dock HDL-associated proteins to apoAI (the main structural protein of HDL) as 3D models through the ICM Molsoft modeling program and obtain certain parameters such as their delta G values. This program models protein-protein… Read More »Modeling the Stability of the High-Density Lipoprotein Particle by Examining the Protein-to-Protein Binding Strengths.
Determining Stability of High- Density Lipoproteins by determining the protein-protein interactions of its associated proteins
Author Name(s) Italia Weaver Faculty Advisor(s) William Munroe Abstract This project focuses on characterizing the stability of the High-Density Lipoprotein (HDL) molecule. HDL predominantly functions as a cholesterol transport molecule and has been shown to associate with a large number of additional proteins unrelated to this function. Here, we aim to understand how tightly these HDL-associated proteins interact with the HDL particle. This was done through the ICM Molsoft program… Read More »Determining Stability of High- Density Lipoproteins by determining the protein-protein interactions of its associated proteins
Author Name(s) Sizzinette HernandezRamie Klocko Faculty Advisor(s) Dr. Emily Fairfax Abstract Microplastic pollution has been an emerging cause for concern over the last decade as we can now see the breadth of its vast disbursement and realizing how difficult it can be to manage. What is much less understood is how these microplastics interact and accumulate on the land as they pass through various watersheds and make their way to… Read More »Nature’s Solution to Plastic Pollution
Comparative singlet oxygen photosensitizer efficiency of berberine, rose bengal, and methylene blue by time course nuclear magnetic resonance (NMR) monitoring of a photochemical 4+2 cycloaddition endoperoxide formation
Author Name(s) Sarah SuKarthikha Sri IndranSohie PalEmma LeAnika ReganMeher JainAashi ShahDavid IglesiasAndrew WangEdward Njoo Faculty Advisor(s) Edward Njoo Abstract Berberine, a natural product alkaloid, has been shown to exert biological activity via in situ production of singlet oxygen, a highly reactive oxygen species, when photo irradiated. Berberine utilizes singlet oxygen in its putative mechanism of action, wherein it forms an activated complex with DNA and photosensitizes triplet oxygen to singlet… Read More »Comparative singlet oxygen photosensitizer efficiency of berberine, rose bengal, and methylene blue by time course nuclear magnetic resonance (NMR) monitoring of a photochemical 4+2 cycloaddition endoperoxide formation
Author Name(s) Natalie Olivares Faculty Advisor(s) Safa Khan Abstract This research project is a living lab that aims to create an open learning database of student-created science experiments. My work involves a collaboration between other CI students, Dr. Khan (a chemistry professor at CI), and faculty from Rio Del Sol, an elementary school in Oxnard, to build STEM experiments for over 577 K-8th students. The experiments are being designed so… Read More »CI Student Generated Science Experiments to Engage the Local Community
Author Name(s) Diana Del Rio Additional Author(s) Kamryn HansenDerek Flores Faculty Advisor(s) Dr. Ahmed Awad Abstract The RNA-dependent RNA-polymerase (RdRp) is a viral nonstructural protein that is tasked with viral transcription, replication, and is central to viral proliferation in its host. As the RdRp enzyme is tied to continuing viral replication, various therapeutic options, particularly nucleoside analogues, have been tested and displayed inhibitory effects on the RdRp. The objective of… Read More »Rational Design of Novel Nucleoside Analogues for the Treatment of SARS-CoV-2 Infections